MSX-122

¥650.00

规格: 5mg

CAS 号:897657-95-3
英文名字:MSX-122
质量标准:>98%,BR
库存详情未设置 SKU: MB0398-1 分类: , 标签:

MSX-122
分子式:C16H16N6分子量:292.34

简介:MSX-122是一种新型的CXCR4部分拮抗剂,IC50约为10 nM。
物理性状及指标:
外观:……………………粉末
溶解性:…………………H2O :Insoluble;Ethanol:Insoluble;DMSO: 3 mg/mL (10.26 mM)
含量:……………………>98%
储存温度:-20℃,避光防潮密闭干燥

生物活性

描述

MSX-122是一种新型的CXCR4部分拮抗剂,IC50约为10 nM。

IC50& Target

CXCR4
~10 nM

体外

MSX-122 is also incapable of blocking the binding of 125I-labeled CXCL12 to CXCR4. MSX-122 appears to be insufficiently large to block all binding sites between CXCR4 and CXCL12. MSX-122 blocks certain CXCR4 functions via binding to the CXCL12-binding site and interfering with CXCR4/CXCL12-mediated signaling. MSX-122 can intervene in the Gαi-signaling pathway (cAMP modulation), but not the Gq-pathway (calcium flux)

体内

MSX-122 blocks bleomycin-induced lung fibrosis involving chemotaxis and homing of CXCR4-positive mesenchymal progenitor cells into the lungs. MSX-122 exhibits anti-inflammatory activity in a carrageenan-induced paw edema model. MSX-122 blocks lung metastasis of breast cancer and SCCHN, and liver metastasis of uveal melanoma in vivo.

细胞实验

  • Cell lines:MDA-MB-231 cells
  • Concentrations:1, 10, 100, and 1000 nM
  • Incubation Time:15 mins
  • Method:

For binding affinity assay, MDA-MB-231 cells cultured in an 8-well slide chamber are preincubated with MSX-122 at 1, 10, 100, and 1000 nM. Then the cells are fixed with 4% formaldehyde and incubated with 50 nM biotinylated TN14003, and followed by Rhodamine staining.
(Only for Reference)

动物实验

  • Animal Models:Male C57BL/6 mice (age 5–6 weeks)
  • Formulation:dissolved in 10% DMSO and 45% 2-hydroxypropyl-β cyclodextrin
  • Dosages:10 mg/kg
  • Administration:i.p. injection
    (Only for Reference)

储液配置及储存:按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。

浓度/体积/质量

1 mg

5 mg

10 mg

1 mM 3.4207 mL 17.1034 mL 34.2067 mL
5 mM 0.6841 mL 3.4207 mL 6.8413 mL
10 mM 0.3421 mL 1.7103 mL 3.4207 mL

【注意】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。

●部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,以上数据仅供参考交流研究之用。

规格

5mg

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