细胞松弛素A

¥1,000.00

规格: 1mg

CAS 号:14110-64-6

英文名字:Cytochalasin A

质量标准:>98%,BR
产品简介:

细胞松弛素A(Cytochalasin A)是真菌Drechslera dematoidea的代谢产物,能抑制酵母属菌株的生长和葡萄糖转运。细胞松弛素A是细胞蛋白酶B的氧化类似物。抑制HIV-1蛋白酶。
别名:Dehydrophomin
分子式:C29H35NO5分子量:477.59
物理性状及指标
外观:……………………白色结晶粉末
熔点:……………………190~191°C
溶解性:…………………溶于DMSO(20mg/ml)、乙醇(20mg/ml),不溶于水.
炽灼残留:………………<0.1%
纯度:……………………>98%

生物活性
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 ofDictyostelium, activating STATc.

溶液配制推荐(仅供参考)
美仑提供的Cytochalasin A为结晶粉末固体形式,可以溶于乙醇或者DMSO,但是很难溶于水,为增强其在水中的溶解性,可以先将细胞松弛素A溶于DMF,然后在溶于水,起溶解性大致为0.05mg/ml in 1:20 DMF/PBS。

用途及描述:

科研试剂

储存条件:

-15~-20°C

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1mg

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