产品简介：
Mitomycin C，是一种广谱抗肿瘤抗生素，对多种癌症有抗癌作用，其作用原理可使细胞的DNA解聚，同时阻碍DNA的复制，从而抑制肿瘤细胞分裂。
分子式：C15H18N4O5 分子量：334.33
物理性状及指标：
产品形式：………………深蓝紫色结晶粉末
溶解性：……………………DMSO：30 mg/mL
*Mitomycin C 水中如溶解不好，如果需要水溶：可尝试按照2mg+48mg氯化钠助溶
含量：……………………≥970 µg/MG
作用机制：它通过与DNA共价反应来抑制DNA合成，在互补的DNA链之间形成交联。这种相互作用阻止了互补DNA链的分离，抑制了DNA复制。
抗菌谱：丝裂霉素C具有很强的抗肿瘤活性，对革兰氏阳性和革兰氏阴性菌有很强的杀菌作用。
Mitomycin C引起双链DNA的交联，导致诱变，抑制DNA合成，该化合物不影响RNA和蛋白质的合成。
抗菌谱：丝裂霉素C具有很强的抗肿瘤活性，对革兰氏阳性和革兰氏阴性菌有很强的杀菌作用。
Mitomycin C引起双链DNA的交联，导致诱变，抑制DNA合成，该化合物不影响RNA和蛋白质的合成。
| 内容来源公开文献，仅供参考 | |
| Target | DNA synthesis |
|---|---|
| In Vitro | C50 and C125: Identical process to “Early Cryo” cells, except that no G418 drug selection was used. Instead, MMC was added to maturation medium (50 or 125ng/mL final concentration) immediately before feeding cells on process days 27 and 29. Cryopreserved on process day 33[1]. |
| In Vivo | Female C57BL/6J strain mice 8 weeks of age obtained from Japan SLC , were bred and treated in conformity with the guidelines for animal experiments at Kanazawa Medical University. They were housed for 1 week with a 12h light–dark cycle in a temperature and humidity controlled room, and were given free access to food and water. After adaptation to the lighting conditions for 1 week, healthy mice were chosen for the investigation.Female C57BL/6J strain mice 8 weeks of age obtained from Japan SLC were bred and treated in conformity with the guidelines for animal experiments at Kanazawa Medical University. They were housed for 1 week with a 12h light–dark cycle in a temperature and humidity controlled room, and were given free access to food and water. After adaptation to the lighting conditions for 1 week, healthy mice were chosen for the investigation[2]. |
| 药代动力学 | The purpose of this study was to investigate the pharmacokinetics of mitomycin C when administered with ifosfamide and cisplatin as part of the mitomycin C, ifosfamide and cisplatin (MIC) regimen. Eleven patients with advanced non-small cell lung cancer, aged 49-73 years, were treated with mitomycin C (6 mg m-2), ifosfamide and cisplatin. Mitomycin C concentrations in plasma and erythrocytes were determined using HPLC with UV absorbance detection at 360 nm. The plasma β half life of mitomycin C was 44 min and the clearance 16.38 L h-1 m-2. A mean erythrocyte/plasma ratio of 0.87 (SD±0.35) was obtained. At low plasma concentrations, mitomycin C was undetectable in the erythrocyte. The mean plasma mitomycin C concentration when this occurred was 50 ng mL-1 (SD±35). The plasma pharmacokinetics of mitomycin C in the MIC regimen are consistent with the pharmacokinetic data obtained as a single agent, or as a component of other chemotherapy regimens. Mitomycin C is taken up into erythrocytes and is detectable within these cells for two hs following injection. The erythrocyte may act as a transporter of this compound in the circulation[3]. |
| 文献链接 |
|
用途及描述：
- 通过联合用药消除癌细胞的抗性促进其凋亡，多种癌症都对抗癌药具有一定的抗性，这极大地限制了其应用于肿瘤治疗的前景，丝裂霉素C能够致敏 一些抗癌药抗性的癌细胞使其恢复对药物的敏感性，显著促进癌细胞凋亡。
- 可与博来霉素、长春新碱治疗宫颈癌；与多柔比星、5-FU治疗胃癌、肺癌、慢性粒细胞白血病、恶性淋巴瘤等。
储存条件：
-20℃，避光防潮密闭干燥
关键词: 丝裂霉素C
- 【注意】
- ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。
●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。