Pembrolizumab

¥1,800.00¥7,000.00

Pembrolizumab
分子式:C6534H10004N1716O2036S46分子量:146KD
简介:Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性和抗肿瘤活性。
别名:MK-3475, lambrolizumab
物理性状及指标:
产品形式:蛋白原液

纯度: Reduced CE-SDS>95%;
Non-reduced CE-SDS>90%;
SEC-HPLC>95%;
Bacterial Endotoxins Test:<5EU/ml;基本可达:<1EU/ml
Residual Proteins of Host Cell: ≤100 ng/mg,基本可达: 1 ng/mg
Exogenous residual DNA: <100pg/mg
Residual Protein A: ≤100 ng/mg

储存条件:-70 ± 15℃for long-term storage, 2-8℃for short-term storage, away from light

运输条件:干冰运输

生物活性(仅来自于公开文献,不保证其有效性)

描述

Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体,同时也是抑制剂,靶向PD-1,具有潜在的免疫检查点抑制活性和抗肿瘤活性。

靶点

PD-1 (Cell-free assay)

体内

除了黑素瘤和肺癌,pembrolizumab在其他晚期实体肿瘤和恶性血液病中同样也具有疗效。Pembrolizumab具有在可接受范围的副作用,在具有晚期非小细胞肺癌的患者中,具有抗肿瘤活性。

实验参考方法(仅来自公开文献,供参考)

细胞实验:

Objective:To examine the effect of high-dose steroid therapy on lymphocyte proliferation/functionality after stimulation with anti-CD3 in the presence of pembrolizumab
Cells:Human PBMCs
Concentrations:5 µg/mL
Incubation Time:–
Method:Isolated PBMCs were pre-treated with prednisone (1 nM – 1 mM) before anti-CD3 stimulation. Anti-CD3-stimulated cells were then incubated with pembrolizumab and their proliferative capacity and IL-2 secretion ability were measured by carboxyfluorescein succinimidyl ester (CFSE) staining and ELISA.
Reference:http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e14587

动物实验

Objective:To evaluate the pharmacokinetics and biodistribution of 89Zr-labeled Pembrolizumab
Animal Models:Female ICR (CD-1) mice, Hsd: Sprague-Dawley outbred rats, NSG mice(humanized mice), hu-PBL-SCID mice(humanized mice)
Formulation:–
Dosages:–
Administration:i.v.
Reference:https://www.ncbi.nlm.nih.gov/pubmed/27493273

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用途及描述:科研试剂,广泛应用于分子生物学,药理学等科研方面,严禁用亍人体。Pembrolizumab (anti-PD-1)是一种有效的、高选择性的、人源IgG4-kappa单克隆抗体。本品适用亍该领域的科研实验,严禁直接用于人体。

我司所售出产品仅供于科研研究用途(非临床科研研究),每次销售产品行为都适用于我司网上所列明的通用销售条款

规格

1mg, 5mg

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