Urolithin A

¥800.00¥3,000.00

CAS 号: 1143-70-0
质量标准:>98%,BR
货号: MB3588

Urolithin A
分子式:C13H8O4分子量:228.20

简介:Urolithin A, a metabolite of ellagitannin, is a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption.
中文名:尿石素A
物理性状及指标:
外观:……………………粉末
溶解性:…………………H2O :Insoluble;Ethanol:Insoluble;DMSO: 46 mg/mL (201.58 mM
含量:……………………>98%
储存温度:-20℃,避光防潮密闭干燥

运输条件:2~8℃运输

生物活性

描述

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A inducesautophagyandapoptosis, suppresses cell cycle progression, and inhibitsDNA synthesis.

体外

Micromolar urolithin A concentrations induces both autophagy and apoptosis. Urolithin A suppresses cell cycle progression and inhibited DNA synthesis in human sw620 colorectal cancer cells.Urolithin A shows antiproliferative effects and inhibits T24 and Caco-2 cell growth with IC50s of 43.9 and 49 μM, respectively.Urolithin A exerts a dose- and time-dependent significant arrest at G2/M and S phases after treatments with 50 and 100 μM at 24 and 48 h compared to control cells. It induces cell apoptosis with 50 and 100 μM.Urolithin A shows potent antiproliferative activity on HepG2 cells. When cell death is induced by Urolithin A, the expression of β-catenin, c-Myc and Cyclin D1 are decreased and TCF/LEF transcriptional activation is notably down-regulated. Urolithin A also increases protein expression of p53, p38-MAPK and caspase-3, but suppresses expression of NF-κB p65 and other inflammatory mediators.

体内:

The volume of paw edema is reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A.

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储液配置及储存:按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。

1 mg

5 mg

10 mg

1 mM

4.3821 mL

21.9106 mL

43.8212 mL

5 mM

0.8764 mL

4.3821 mL

8.7642 mL

10 mM

0.4382 mL

2.1911 mL

4.3821 mL

50 mM

0.0876 mL

0.4382 mL

0.8764 mL

【注意】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。

●部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,以上数据仅供参考交流研究之用。

我司所售出产品仅供于科研研究用途(非临床科研研究),每次销售产品行为都适用于我司网上所列明的通用销售条款

规格

10mg, 50mg

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