Allopregnanolone

¥1,000.00

规格: 10mg

CAS 号:516-54-1
英文名字:Allopregnanolone
质量标准:>98%,BR
SKU: MB3607-1 分类: , 标签:

Allopregnanolone
分子式:C21H34O2分子量:318.49

简介:Allopregnanolone是一种神经类固醇,在脑内由黄体酮合成而来,是高效的GABAA receptor正向别构调节剂。
物理性状及指标:
外观:……………………粉末
溶解性:…………………H2O :Insoluble; DMSO: 64 mg/mL (200.95 mM);Ethanol:31 mg/mL (97.33 mM)
含量:……………………>98%
储存温度:-20℃,避光防潮密闭干燥

运输条件:2~8℃运输

生物活性

描述

Allopregnanolone is under investigation for the treatment of Super-Refractory Status Epilepticus.Allopregnanolone has been investigated for the treatment of Severe Postpartum Depression.

IC50& Target

GABA,

体外

Allopregnanolone induces a significant increase in proliferation of neuroprogenitor cells derived from the rat hippocampus and human neural stem cells derived from the cerebral cortex in a dose-dependent manner. Allopregnanolone increases the expression of genes that promote mitosis and inhibits the expression of genes that repress cell proliferation. Its biosynthesis begins with progesterone, which is converted to dihydroprogesterone by the enzyme 5α-DHP and after that, the enzyme 3α-HSOR catalyses the reduction of dihydroprogesterone toward allopregnanolone.

体内

  • Allopregnanolone increases both the K+-evoked [3H]-glutamate and [3H]-GABA release in P rats. The neurosteroid also increases the basal release of [3H]-glutamate in VO rats in an effect that is dependent on the modulation of NMDA receptors as is reverted by Mg2+. At therapeutic doses by either subcutaneous or intravenous routes, allopregnanolone mouse plasma levels range between 34-51ng/mL by 30min. Allopregnanolone-induced neurogenesis correlates with restoration of learning and memory function in a mouse model of Alzheimer’s disease and is comparably efficacious in aged normal mice. Progesterone and allopregnanolone has shown neuroprotective effects in different experimental models including stroke and spinal cord injury.

储液配置及储存:按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。

浓度/体积/质量

1 mg

5 mg

10 mg

1 mM 3.1398 mL 15.6991 mL 31.3982 mL
5 mM 0.6280 mL 3.1398 mL 6.2796 mL
10 mM 0.3140 mL 1.5699 mL 3.1398 mL
50 mM 0.0628 mL 0.3140 mL 0.6280 mL

【注意】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。

●部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,以上数据仅供参考交流研究之用。

规格

10mg

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