BisindolylmaleimideI(GF109203X)

¥200.00¥600.00

CAS 号: 133052-90-1
货号: MB4234

GF-109203X

分子式:C25H24N4O2 分子量:412.48

产品描述

GF109203X是有效的PKC抑制剂,抑制PKCα, PKCβI, PKCβII,和PKCγ,IC50分别为20 nM, 17 nM, 16nM,和20 nM,作用于PKC比作用于EGFR, PDGFR和胰岛素受体选择性高3000倍以上。

靶点

PKCα PKCβI PKCβII PKCγ

IC50

20 nM 17 nM 16 nM 20 nM

体外研究

GF109203X, as an ATP-competitive PKC inhibitor, prevents platelet aggregation induced by stimuli that activate PKC, and has the potential as a tool for studying the involvement of PKC in signal transduction pathways. [1] GF 109203X produces reversal activity on P-glycoprotein and MRP -mediated multidrug resistance. [2] [3] PKC inhibition by GF109203X significantly reduces carbachol-stimulated ERK1/2 activation and the subsequent proliferation of SNU-407 colon cancer cells. [ – See more at: http://www.selleckchem.com/products/gf109203x.html#sthash.sDMz4BKs.dpuf

体内研究

溶解性

DMSO 82 mg/mL,水<1 mg/mL,乙醇<1 mg/mL

稳定性

2年-20°C粉状,6月-80°C溶于DMSO

特征

运输条件:2~8℃运输

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规格

1mg, 5mg

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