Z-IETD-FMK是一种特异性Caspase-8抑制剂。
理化数据
| 分子量 |
654.68 |
|
化学式 |
C30H43FN4O11 |
|
CAS号 |
210344-98-2 |
|
稳定性 |
3 years -20°C powder |
|
2 years -80°C in solvent |
溶解性
| DMSO |
91 mg/mL (138.99 mM) |
|
Water |
<1 mg/mL 难溶或者不溶 |
|
Ethanol |
<1 mg/mL 难溶或者不溶 |
生物活性
| 产品描述 | Z-IETD-FMK是一种特异性Caspase-8抑制剂。 | |
| 靶点 |
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|
| 体外研究 | Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. | |
| 体内研究 | In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries |
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