氯氮平氮氧化合物

¥800.00

规格: 10mg

CAS 号:34233-69-7
英文名字:Clozapine N-oxide
质量标准:>98%,BR
库存详情未设置 SKU: MB4734-1 分类: , ,

溶解性:DMSO:20mg/ml.

熔点:255-260 °C

生物活性:Clozapine N-oxide is a major metabolite of Clozapine noted to decrease SR-2A (5-HT2 serotonin receptor) density in vitro.

Clozapine N-oxide was noted to decrease 5-HT2 serotonin receptor density in rat primary cortical cells and human hippocampal SHS5Y5 neuroblastoma cells.

in vitro: Clozapine and N-desmethylclozapine antagonized 5-HT-stimulated phosphoinositide hydrolysis with IC50 values of 110 and 29.4 nM, respectively. Clozapine N-oxide was less potent [1].

in vivo: When administered clozapine, mean CNO plasma concentrations of 17.7 +/- 16.4 ng/ml were slightly lower than the other clozapine metabolite-desmethylclozapine (DCLOZ) plasma levels of 24.4 +/- 8.6 ng/ml at the 12 hour time point. When CNO was administered, plasma concentrations at the 12 hour time point of clozapine were twice the amount of CNO (28.1 +/- 8.9 ng/ml vs 14.4 +/- 8.8 ng/ml) [2]. Clozapine and its metabolite clozapine-N-oxide (0.5 mg/kg) were administered intraperitoneally to guinea-pigs. Significant amounts of clozapine were detected in plasma, liver, frontal cortex and caudate after clozapine-N-oxide administration [3].

保存条件:-20℃,避光防潮密闭干燥

运输条件:-2~8℃运输

备注:库存情况可能有所变动,请与我们销售人员确认为准,价格情况请直接联系我们销售人员。

规格

10mg

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