特非那定, Terfenadine
分子式：C32H41NO2 分子量：471.67
外观：白色至类白色粉末
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溶解性 |
chloroform: soluble250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow |
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H2O: soluble0.01mg/mL at30°C |
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1 M HCl: soluble0.12 mg/mL at30°C |
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hexane: soluble0.34 mg/mL at30°C |
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0.1 M tartaric acid: soluble0.45 mg/mL |
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0.1 M citric acid: soluble1.1 mg/mL |
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methanol: soluble37.5 mg/mL at30°C |
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ethanol: soluble in salt form37.8 mg/mL at30°C |
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储存温度 |
2-8°C |
运输条件：常温运输
生物活性：非镇静类组胺H1受体拮抗剂；
Terfenadine inhibits HERG (human ether-a-gogo-related gene) K+ channels It also blocks the delayed rectifier potassium current (IK) of rat isolated ventricular myocytes with IC50 value of 5.96 μM.
Non-sedating second generation H1 histamine receptor antagonist. Mainly metabolized by Cyp3A4, 5, 7. Inhibits CYP2C8.
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