Terfenadine

¥500.00

规格: 1g

库存详情未设置 SKU: MB7368-1 分类: , 标签:

特非那定, Terfenadine
分子式:C32H41NO2 分子量:471.67
外观:白色至类白色粉末

溶解性

chloroform: soluble250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow

H2O: soluble0.01mg/mL at30°C

1 M HCl: soluble0.12 mg/mL at30°C

hexane: soluble0.34 mg/mL at30°C

0.1 M tartaric acid: soluble0.45 mg/mL

0.1 M citric acid: soluble1.1 mg/mL

methanol: soluble37.5 mg/mL at30°C

ethanol: soluble in salt form37.8 mg/mL at30°C

储存温度

2-8°C

运输条件:常温运输

生物活性:非镇静类组胺H1受体拮抗剂;
Terfenadine inhibits HERG (human ether-a-gogo-related gene) K+ channels It also blocks the delayed rectifier potassium current (IK) of rat isolated ventricular myocytes with IC50 value of 5.96 μM.
Non-sedating second generation H1 histamine receptor antagonist. Mainly metabolized by Cyp3A4, 5, 7. Inhibits CYP2C8.

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规格

1g

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