产品简介：
Bictegravir是一种新型的、有效的HIV-1 integrase抑制剂。
分子式：C21H18F3N3O5 分子量：449.38
中文名：比克替拉韦
物理性状及指标：
外观：……………………粉末
溶解性：…………………H2O ：Insoluble；Ethanol：Insoluble；DMSO: 90 mg/mL (200.28 mM)
含量：……………………>98%
储存温度：-20℃，避光防潮密闭干燥
运输条件：
2~8℃运输
| 描述 | Bictegravir是一种新型的、有效的HIV-1 integrase抑制剂。 |
|---|---|
| IC50& Target | IC50: 7.5 nM (HIV-1 integrase) |
| 体外 | Bictegravir exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes, with 50% effective concentrations ranging from 1.5 to 2.4 nM and selectivity indices up to 8,700 relative to cytotoxicity. Bictegravir inhibits the strand transfer activity with an IC50 of 7.5 ± 0.3 nM. Relative to its inhibition of strand transfer activity, Bictegravir is a much weaker inhibitor of 3′-processing activity of HIV-1 integrase, with an IC50 of 241 ± 51 nM. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ∼6,800 in MT-2 cells and ∼1,500 in MT-4 cells. |
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2253 mL | 11.1264 mL | 22.2529 mL |
| 5 mM | 0.4451 mL | 2.2253 mL | 4.4506 mL |
| 10 mM | 0.2225 mL | 1.1126 mL | 2.2253 mL |
| 50 mM | 0.0445 mL | 0.2225 mL | 0.4451 mL |
按表中溶解性配置；如溶解困难，可以通过快速搅拌，超声或温和加热（在45-60°C下水浴）。液体稳定性报道的很少，建议现配现用，如需储存，建议：-20℃1-3月；-80℃ 3-6月。
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●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。
