Tegafur
分子式:C8H9FN2O3分子量:200.17
简介:Tegafur是抗癌剂5-FU的前药。
中文名:替加氟
物理性状及指标:
外观:……………………白色结晶性粉末
熔点:……………………164~171℃
溶解性:…………………DMSO : ≥ 48 mg/mL(239.80 mM)
密度:……………………1.46 g/cm3
干燥失重:………………≤0.5%
含量:……………………≥98%
生物活性
描述 | Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. |
IC50& Target |
Nucleoside antimetabolite/analog |
体外 |
Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity. |
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储液配置及储存:按表中溶解性配置;如溶解困难,可以通过快速搅拌,超声或温和加热(在45-60°C下水浴)。液体稳定性报道的很少,建议现配现用,如需储存,建议:-20℃1-3月;-80℃ 3-6月。
运输条件:常温运输
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1 mg |
5 mg |
10 mg |
1 mM |
4.9958 mL |
24.9788 mL |
49.9575 mL |
5 mM |
0.9992 mL |
4.9958 mL |
9.9915 mL |
10 mM |
0.4996 mL |
2.4979 mL |
4.9958 mL |
【注意】
●我司产品为非无菌包装,若用于细胞培养,请提前做预处理,除去热原细菌,否则会导致染菌。
●部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,以上数据仅供参考交流研究之用。