产品简介：
Kevetrin hydrochloride是水溶性的p53激活剂，具有潜在的抗肿瘤活性。
分子式：C5H10ClN3S
分子量：179.67
物理性状及指标：
外观：……………………粉末
溶解性：…………………H2O ：36 mg/mL (200.37 mM)；Ethanol：21 mg/mL (116.88 mM) ；DMSO: 36 mg/mL (200.37 mM)
含量：……………………>98%
储存温度：-20℃，避光防潮密闭干燥
| 描述 | Kevetrin盐酸盐是一种肿瘤抑制蛋白p53的激动剂, 具有潜在的抗肿瘤活性。 |
|---|---|
| Description | Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53 in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin’s development potential in this area. |
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.5658 mL | 27.8288 mL | 55.6576 mL |
| 5 mM | 1.1132 mL | 5.5658 mL | 11.1315 mL |
| 10 mM | 0.5566 mL | 2.7829 mL | 5.5658 mL |
| 50 mM | 0.1113 mL | 0.5566 mL | 1.1132 mL |
按表中溶解性配置；如溶解困难，可以通过快速搅拌，超声或温和加热（在45-60°C下水浴）。液体稳定性报道的很少，建议现配现用，如需储存，建议：-20℃ 1-3月；-80℃ 3-6月。
- 【注意】
- ●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。
●部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，以上数据仅供参考交流研究之用。