Kevetrin HCl
分子式：C5H10ClN3S分子量：179.67
简介：Kevetrin hydrochloride是水溶性的p53激活剂，具有潜在的抗肿瘤活性。
物理性状及指标：
外观：……………………粉末
溶解性：…………………H2O ：36 mg/mL (200.37 mM)；Ethanol：21 mg/mL (116.88 mM) ；DMSO: 36 mg/mL (200.37 mM)
含量：……………………>98%
储存温度：-20℃，避光防潮密闭干燥
生物活性
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描述
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Kevetrin盐酸盐是一种肿瘤抑制蛋白p53的激动剂, 具有潜在的抗肿瘤活性。 |
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Description |
Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53 in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin’s development potential in this area. |
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MB2623
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Kevetrin HCl |
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NSC 319726 |
储液配置及储存：按表中溶解性配置；如溶解困难，可以通过快速搅拌，超声或温和加热（在45-60°C下水浴）。液体稳定性报道的很少，建议现配现用，如需储存，建议：-20℃1-3月；-80℃ 3-6月。
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1 mg |
5 mg |
10 mg |
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1 mM |
5.5658 mL |
27.8288 mL |
55.6576 mL |
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5 mM |
1.1132 mL |
5.5658 mL |
11.1315 mL |
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10 mM |
0.5566 mL |
2.7829 mL |
5.5658 mL |
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50 mM |
0.1113 mL |
0.5566 mL |
1.1132 mL |
【注意】
●我司产品为非无菌包装，若用于细胞培养，请提前做预处理，除去热原细菌，否则会导致染菌。
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